About Down's Syndrome : Respiratory Tract Infections in Children with Down’s Syndrome

Kings College London logo   Arial Circular Logo_hires   UCL Institute of Child Health logo   FARR logo   Evidence based ENT logo

Respiratory Tract Infections in Children with Down’s Syndrome

Towards Better Management Using Health Informatics and Working With Their Carers


The DSA will be supporting the research by reviewing study protocols, publications and presentations and disseminating the results of the research findings.

One in every 1000 UK babies are born with Down’s syndrome and individuals with Down’s syndrome are more likely suffer from frequent ear, sinus, throat and lung infections. They are also more likely than the rest of the population to have complications after such infections.  However because adults and children with Down’s syndrome are rarely included in research studies, the best way to manage and treat these infections for people with the condition is not clear. Dr Logan Manikam (NIHR Doctoral Research Fellow, University College London Institute of Child Health) hopes that his research into respiratory tract infections will improve healthcare in this area for people with Down’s syndrome.

This research will link NHS data on GP visits and hospital admissions to the use of vaccines and antibiotics. The research team will work with the families of children with Down’s syndrome to find out what difficulties respiratory tract infections in their children places upon them. The information will help to develop tools to better research the benefits of different treatments. Anonymous data from GP and hospital records will be used to look at how respiratory tract infections are managed for people with Down’s syndrome. Data examined will include the way in which antibiotics and vaccine have been used and evaluate how effective this has been. Dr Manikam hopes his research will help healthcare professionals such as GPs, paediatricians and Ear Nose and Throat surgeons to develop recommendations for managing respiratory tract infections. It is hoped that this information will provide the best evidence available for people with Down’s syndrome and their parents and carers to jointly make decisions with their health care professional about the right treatment for them.

The project will also involve a systematic review of all existing literature on respiratory tract infections. Firstly to identify the different ways in which respiratory tract infections have been dealt with both currently and in the past., leading to a better understanding of all the treatment options available and a better understanding of the best ways to prevent and treat respiratory tract infections in people with Down’s syndrome in the future.

Download Respiratory Tract Infections Leaflet for Parents